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R. Singh, D. Raj, R. Lagnado, M. Mathew, A. Abedin, H. Manku, H. Dua; Alcohol Delamination Of The Corneal Epithelium In The Management Of Recurrent Corneal Erosions – A Prospective Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5014.
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To investigate the efficacy of alcohol delamination in the management of recurrent corneal erosions (RCE).
A prospective consecutive case series of 20 patients with RCE who did not respond to conservative management with topical lubrication and/or a bandage contact lens and were treated by alcohol delamination. The corneal epithelium over the affected area was removed by the application of 20% alcohol for 30 seconds. Post operatively the eyes were treated with antibiotic drops and artificial tears. The duration and frequency of painful episodes together with a visual analogue pain score were used to assess efficacy of treatment. Follow up was for up to 38 months.
Complete follow up was attained for 17 patients for a mean of 24 months (range 12–38). Fourteen of the 17 of patients (85%) had complete relief of symptoms after a single treatment. Three patients with persistent symptoms reported them to be much less severe and did not feel they needed further treatment. One patient developed transient subepithelial haze following therapy, one patient developed a herpetic infection 2 months following treatment that resolved with treatment and one patient had a change in their refractive error. No loss of vision was seen in any patient.
Alcohol delamination appears to be a safe and effective alternative in the management of recurrent corneal erosions. Unlike other methods, the removed epithelium is available as a sheet that may be subjected to further examination, though some of the changes observed may reflect the effect of alcohol on the epithelium.
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