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A. Kozaki, E. Taji, R. Inoue, T. Maeda, T. Inoue, Y. Inoue, H. Yoshimura, K. Ito; Ocular Manifestation At The Time Of Diagnosis In Japanese Patients With Untreated Grave's Disease . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5072.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ocular manifestation at early stage of Graves' Ophthalmopathy which is usually observed in the advance stage of ophthalmopathy in order to manage or treat ophthalmologically.
One hundred eighty two patients; male 27, female 155; average age 37.6 years old ( range 12 ∼ 79 ) were employed. These patients were consecutively examined at eye hospital in collaboration of endocrinological hospital ( Ito ). All patients haven't been treated endocrinologically. Ophthalmic examination and MRI were implemented in all patients.
Fifty five percent of patients took the precedence of physical symptom, 17% of cases took the precedence of ocular manifestation. Exophthalmos reading 15.3±3.0 mm. Height of palpebral fissure 8.8±1.2 mm, prevalence of Dalrymple sign 51.6%, Graefe sign 48.9%, eyelid swelling 35.1%, swelling of lacrimal gland 19.8%, enlargement of extra ocular muscle 9.3%, disturbance of eye movement 4.4%, no case of optic nerve involvement. These ocular involvements were compared to previous report ( Kozaki et al ; 2004 ARVO 2717 ).
Ocular involvement was observed in about 50 % of patients with Graves' disease. It was considered that the onset of ophthalmopathy may be immediate at the time of diagnosis of Graves' disease.
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