May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Oxygen Saturation In Retinal Vein Occlusion
Author Affiliations & Notes
  • S.H. Hardarson
    University of Iceland, Reykjavik, Iceland
    Ophthalmology,
  • R.A. Karlsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • G.H. Halldorsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • S.R. Joelsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • T. Eysteinsson
    University of Iceland, Reykjavik, Iceland
    Ophthalmology,
  • J.A. Benediktsson
    University of Iceland, Reykjavik, Iceland
    Electrical and Computer Engineering,
  • J.M. Beach
    Institute for Technology Development, Stennis Space Center, MS
  • E. Stefansson
    University of Iceland, Reykjavik, Iceland
    Ophthalmology,
  • Footnotes
    Commercial Relationships  S.H. Hardarson, Oxymap ehf., E; Oxymap ehf., P; R.A. Karlsson, Oxymap ehf., E; Oxymap ehf., P; G.H. Halldorsson, Oxymap ehf., E; Oxymap ehf., P; S.R. Joelsson, Oxymap ehf, E; T. Eysteinsson, Oxymap ehf., I; Oxymap ehf., E; Oxymap ehf., P; J.A. Benediktsson, Oxymap ehf., I; Oxymap ehf., E; Oxymap ehf., P; J.M. Beach, Oxymap ehf., I; Oxymap ehf., P; E. Stefansson, Oxymap ehf., I; Oxymap ehf., E; Oxymap ehf., P.
  • Footnotes
    Support  Icelandic Research Council, Icelandic Fund for Prevention of Blindness
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5196. doi:
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      S.H. Hardarson, R.A. Karlsson, G.H. Halldorsson, S.R. Joelsson, T. Eysteinsson, J.A. Benediktsson, J.M. Beach, E. Stefansson; Oxygen Saturation In Retinal Vein Occlusion . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5196.

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Abstract
 
Purpose:
 

A non–invasive study of the oxygen saturation of retinal venules in eyes with retinal vein occlusion (RVO) and how laser treatment affects the oxygen saturation.

 
Methods:
 

Our automatic non–invasive retinal oximeter yields fundus images with 4 wavelengths of light simultaneously and calculates optical density ratio, which is linearly related to hemoglobin oxygen saturation (SO2). We performed oximetry in 7 patients with RVO. We measured the healthy fellow eye, and retinal venules outside and inside the occluded area in the RVO eye before and after laser treatment. Differences were analyzed with two–way ANOVA and Bonferroni post tests and with a paired t–test.

 
Results:
 

The venular SO2 was 59±6% in healthy fellow eyes (mean±SD; n=5), 60±12% in non–occluded areas of RVO eyes (n=4), 39±23% before laser in occluded venules (n=5) and 56±4% in occluded venules following laser treatment (n=5). Before laser the occluded venules have a significantly lower SO2 than healthy eyes or non–occluded areas of RVO eyes (p<0.05) and the SO2 was normalized by laser treatment. In the 4 eyes measured both before and after laser treatment the SO2 rose from 38±26% to 57±4% (p= 0.24, paired t–test). The figure shows a pseudocolor SO2 map before and after laser treatment.

 
Conclusions:
 

The automatic non–invasive retinal oximeter demonstrates decreased oxygen saturation in occluded retinal venules compared with healthy areas of the RVO eyes and healthy eyes. Laser treatment in RVO brings the oxygen saturation back to normal values.  

 
Keywords: vascular occlusion/vascular occlusive disease • laser • imaging/image analysis: clinical 
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