May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Early Detection of Chloroquine / Hydroxychlororquine Retinopathy: Comparison of Fundus Autofluorescence and Multifocal Electroretinography
Author Affiliations & Notes
  • U. Kellner
    Retina Science, Bonn, Germany
    AugenZentrum Siegburg, Siegburg, Germany
  • A.B. Renner
    Dept. of Ophthalmology, Charite Campus Benjamin Franklin, Berlin, Germany
  • H. Tillack
    Dept. of Ophthalmology, Charite Campus Benjamin Franklin, Berlin, Germany
  • Footnotes
    Commercial Relationships  U. Kellner, None; A.B. Renner, None; H. Tillack, None.
  • Footnotes
    Support  DFG Ke442/11–1,2
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5199. doi:
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      U. Kellner, A.B. Renner, H. Tillack; Early Detection of Chloroquine / Hydroxychlororquine Retinopathy: Comparison of Fundus Autofluorescence and Multifocal Electroretinography . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5199.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the value of fundus autofluorescence (FAF) measurements in early detection of chloroquine/hydroxychloroquine retinopathy.

Methods: : In a consecutive series of 22 patients with long–term chloroquine or hydroxychloroquine treatment (duration more than one year) with or without visual disturbances FAF imaging was performed with the Heidelberg Retina Angiograph. In addition, multifocal electroretinography (mfERG) was performed according to ISCEV standards.

Results: : In 9/22 patients alterations of FAF were observed. Mild changes were limited to a pericentral ring of increased autofluorescence. More advanced stages presented as pericentral mottled loss of autofluorescence with increased autofluorescence in the adjacent retina and later on a complete loss of pericentral autofluoresence. In one case a pericentral ring was observed when ophthalmoscopy and fluorescein angiography were normal. Marked progression of FAF abnormalities could be observed during 3–5 years follow–up in 2/3 patients. With the mfERG, pericentral amplitude reductions were detected in all patients with FAF abnormalities but in additional 4 patients with normal FAF.

Conclusions: : FAF imaging can be reliably used to detect early retinal pigment epithelial alterations in chloroquine/hydroxychloroquine retinopathy. Ophthalmoscopy and fluorescein angiography appear to be less sensitive, but the mfERG appears to be more sensitive than FAF imaging.

Keywords: retinal pigment epithelium • electroretinography: clinical • imaging/image analysis: clinical 
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