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A.J. Williams, S. Fekrat; Progression of Choroidal Neovascularization Following a Single Injection of Pegaptanib Sodium (Macugen®) in Two Eyes With Neovascular Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5230.
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© ARVO (1962-2015); The Authors (2016-present)
To describe two cases of neovascular age–related macular degeneration that progressed despite a single intravitreal injection of pegaptanib (Macugen®) six weeks earlier.
A 62–year–old man and a 76–year–old woman with occult and minimally classic lesions, respectively, each received a single injection of intravitreal Macugen.
Within six weeks of an intravitreal Macugen injection, the choroidal neovascular lesions progressed. In one eye, the chronic occult lesion developed a subfoveal classic CNV component. In the other eye, the classic component of the minimally classic lesion tripled in size.
A single dose of intravitreal Macugen was not effective in these two cases at six weeks. This report reminds the ophthalmologist to consider obtaining a fluorescein angiogram
during follow–up after an intravitreal Macugen injection to monitor
CNV lesion characteristics, particularly if the visual acuity
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