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N. Patel, R.A. Grigorian, M.A. Zarbin, N. Bhagat; Effect of 5–Fluorouracil and Fragmin in the Development of Proliferative Vitreo–Retinopathy . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5269.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of 5–Fluorouracil (5–FU) and fragmin (low molecular weight heparin) on rhegmatogenous retinal detachments with proliferative vitreoretinopathy (PVR)
Retrospective review of 4 cases who underwent pars plana vitrectomy (PPV) for retinal detachment (RD) with PVR using 5–FU and Fragmin.
Mean follow up of these patients is 16.5 months (ranged between 12–24 months). All patients had anatomic success at the last follow up. One patient developed mild retinal tractional epiretinal membrane in the inferior periphery which has been stable and has required no surgical intervention.
5–FU and fragmin can safely be used in retinal detachment repair. A large prospective study is needed to assess the effect of 5–FU and fragmin for the development of PVR.
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