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M.M. Pagliara, D. Lepore, A. Baldascino, R. De Santis, G. D'Amico, C. Angora, M. Laguardia, L. Orazi, F. Molle, E. Balestrazzi; Fluorescein Angiographic Findings in Zone I ROP . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5302.
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to evaluate fluorescein angiographic findings in zone I ROP undergoing laser treatment and compare with laser outcomes.
starting from Dec‘04 RETCAM digital fluorescein angiography (Massie Lab. , Pleasanton, CA) became available for ROP screening in the neonatal intensive care unit at the Catholic University Hospital in Rome. Since then 68 inborn preterm with gestational age (GA) ≤32 wks and/or a birth weight (BW) ≤1500gr were screened for ROP. The mean BW was 1098.9 gr. (range 565–2100gr.) and the mean GA was 29.00 wks (range 24–33wks). ROP was diagnosed in 22 infants (mean BW 921.6gr., GA 27.3wks). 6 babies (mean BW 835.0 gr., mean GA 25.7wks) were classified type1 zone 1 pre–threshold ROP and consequently underwent laser photoablation of avascular retina. In all cases digital fluorescein angiography was performed before treatment.
fluorescein angiography allow to visualise shunt, revascularization and leakage at the junction between vascular and avascular retina. In 3 of the 5 eyes (41,7%) that progressed to stage 4b or 5 despite laser, was possible to observe small non perfused area and/or leakage inside the vascularised retina.
Fluorescein angiography was useful to distinguish the deceptively featureless zone 1 junction between vascularized and non–vascularized retina. Further studies are needed to understand the role of vascular abnormalities observed in zone 1 vascularized retina.
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