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A. Baldascino, A. Capone, D. Lepore, F. Molle, E. Balestrazzi, M.T. Trese; Maternal Autologous Plasmin Enzyme–Assisted Vitrectomy for Posterior Hyaloidal Contraction . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5307.
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Autologous plasmin enzyme (APE) has previously been reported to be helpful in facilitating vitreous separation in complicated vitreoretinal surgery for retinopathy of prematurity (ROP).The purpose of this study is to determine if maternally derived plasmin enzyme (MDPE) can be used safely to facilitate the lamellar dissection of the hyaloid from the retinal surface of eyes with diffuse posterior hyaloidal contraction.
Retrospective, noncomparative interventional case series of eyes from infants, who underwent MDPE–assisted vitrectomy for tractional retinal detachment due to diffuse posterior hyaloidal contraction.
Three eyes of 2 infants comprise the study cohort. Mean postmenstrual age at surgery was 87 weeks. Both children had undergone prior vitrectomy. All eyes were reattached surgically. There were no complications associated with the use of MDPE. Visual outcome is generally limitied by the degree of retinal thinning.
MDPE can be safely employed to facilitate manual dissection of the hyaloid from the retinal surface in infants with persistent retinal detachment due to diffuse posterior hyaloidal contraction.
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