May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Perturbation of the Meibomian Glands and the Effect on Tear Film Stability and Tear Film Break Up Patterns (TFBUP) in an Ashkenazi Jewish Population
Author Affiliations & Notes
  • M.R. Schindelar
    ORA Clinical Research and Development, North Andover, MA
  • G.W. Ousler, III
    ORA Clinical Research and Development, North Andover, MA
  • S.L. Oberoi
    ORA Clinical Research and Development, North Andover, MA
  • M.B. Abelson
    ORA Clinical Research and Development, North Andover, MA
    Harvard Medical School and Schepens Eye Research Institute, Boston, MA
  • Footnotes
    Commercial Relationships  M.R. Schindelar, None; G.W. Ousler, None; S.L. Oberoi, None; M.B. Abelson, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5610. doi:
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      M.R. Schindelar, G.W. Ousler, III, S.L. Oberoi, M.B. Abelson; Perturbation of the Meibomian Glands and the Effect on Tear Film Stability and Tear Film Break Up Patterns (TFBUP) in an Ashkenazi Jewish Population . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5610.

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Abstract
 
Purpose:
 

The purpose of this study was to massage the eyelids to express meibomian glands and examine the impact on tear film stability as measured by tear film break up time (TFBUT) and tear film break up pattern (TFBUP) in dry eye patients.

 
Methods:
 

Thirty subjects of Ashkenazi Jewish descent who have been diagnosed with dry eye underwent ophthalmic evaluations including a slit–lamp biomicroscopy, visual acuity, meibomian gland assessment, blink rate, TFBUT and TFBUP. After baseline assessment the investigator massaged the eyelids, meibomian glands were examined for clarity and percent expression and TFBUT and TFBUP were repeated.

 
Results:
 

Forty–five (45) eyes were able to express lipid from their meibomian glands, a significant change (p = 0.006) in pattern distribution was observed and the results tabulated below: It was also observed that 15 eyes were unable to effectively express lipid.  

 
Conclusions:
 

The data shows that the effective expression of meibomian lipids significantly changes the incidence of each pattern. It was observed that incidence of the spotting pattern doubled in the population that was able to express lipid.

 
Keywords: cornea: tears/tear film/dry eye • cornea: clinical science • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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