May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Central Cornea Thickness Is Increased In Patients With Ocular Coloboma
Author Affiliations & Notes
  • J. Tang
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD
  • P.A. Gokhale
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA
  • S.E. Brooks
    Eye Consultants of Augusta, Augusta, GA
  • D. Blain
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD
  • B.P. Brooks
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD
  • Footnotes
    Commercial Relationships  J. Tang, None; P.A. Gokhale, None; S.E. Brooks, None; D. Blain, None; B.P. Brooks, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5611. doi:
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      J. Tang, P.A. Gokhale, S.E. Brooks, D. Blain, B.P. Brooks; Central Cornea Thickness Is Increased In Patients With Ocular Coloboma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5611.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Uveal coloboma is a developmental abnormality of the eye caused by failure of the optic fissure to close during the fifth week of gestation. To characterize the anatomy of colobomatous eyes, we have analyzed the central corneal thickness (CCT) in 4 consecutive patients diagnosed with ocular coloboma.

Methods: : This was a consecutive case series of 4 patient with uveal coloboma evaluated at the National Eye Institute. Each patient underwent full ophthalmological examination including measurements of their CCT.

Results: : We describe significantly increased CCT in 3 of 4 consecutive patients with ocular coloboma.

Conclusions: : In all four cases, the corneas of our patients appeared to be of normal thickness clinically; however, corneal pachymetry demonstrated significantly increased CCT in 3 of the 4 patients. Increased CCT may artifactually elevate IOP on Goldmann applanation tonometry. These observations should be born in mind before instituting glaucoma treatments in coloboma patients with apparently elevated IOP. Our report highlights the need to consider the measurement of CCT in patients presenting with ocular colobomas.

Keywords: development • cornea: clinical science • intraocular pressure 
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