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J. Sakamoto, M. Osako, H. Goto, H. Yokoi, M. Miura, M. Usui; Performance of Humphrey Matrix in the Detection of Macular Disease . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5670.
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© ARVO (1962-2015); The Authors (2016-present)
Humphrey Matrix is a second–generation perimeter of frequency doubling technology (FDT). Humphrey Matrix is able to present a smaller size target (2×2 degrees) compared with the original FDT, and a high–resolution analysis can be obtained. Although FDT was originally developed for the diagnosis of glaucoma, Chris Johnson indicates that Humphrey Matrix is a promising tool for the detection of macular diseases. We studied the performance of Humphrey Matrix in the detection of macular disease.
Twenty–four eyes of 24 patients with macular disease (mean age: 61.0±12.3 year) and 12 eyes of 12 normal persons were studied (mean age: 58.8±10.1 year). The macular diseases were preretinal membrane in 11 eyes, macular hole in 2 eyes, macular degeneration in 3 eyes, detachment of retinal pigment epithelium in 2 eyes, age related macular degeneration in 3 eyes, and central serous retinochoroidopathy in 2 eyes. The 10–2 program of Humphrey Field Analyzer (HFA) and Humphrey Matrix were performed on each subject.
HFA and Humphrey Matrix detected macular disease at sensitivity of 67% and 88%, and specificity of 100% and 100%, respectively. All 16 patients who had abnormal HFA results also showed abnormal results on Humphrey Matrix, whereas 5 of 8 patients who had normal HFA results had abnormal Humphrey Matrix results. The correlation between MD determined by HFA (x) and that determined by Humphrey Matrix (y) is shown as y=0.95x–3.00 (r=0.79, p<0.0001), and the correlation of PSD was y=0.40x+3.20 (r=0.74,p<0.0001).
Visual field indices (MD and PSD) obtained by HFA and Humphrey Matrix correlate significantly, and Humphrey Matrix is more sensitive than HFA in the detection of macular diseases.
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