Purchase this article with an account.
J.B. Ruddle, A.W. Hewitt, L.S. Kearns, J.R. MacKinnon, S.A. Brown, N.G. Martin, D.A. Mackey; The Heritability of the Interpupillary Distance . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5822.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
A classic twin study was performed to determine the heritability of interpupillary distance (IPD).
The concordance of IPD between monozygotic (MZ) and dizygotic (DZ) twins was compared. A total of 316 twin pairs (102 MZ and 214 DZ) were recruited from two centres: The Twin Eye Study in Tasmania and the Brisbane Adolescent Twin Study. As part of an extensive ophthalmic evaluation, IPD was measured by Humphrey–598 autorefractor during precycloplegic and post cycloplegic refractions. Structural equation modelling with the Mx program was used to determine the heritability of IPD.
The mean +/– SD age of subjects was 25.9 +/– 14.5 years. The mean +/– SD IPD of all eyes examined was 60.1 +/– 3.8 mm. Suggesting a strong genetic influence, the IPD measurements correlated more highly in MZ twins than in DZ twins, with intraclass correlation coefficients of 0.75 and 0.48 respectively. A model of additive genetic and unique environmental effects provided the best fit, yielding a heritability of 61.9% (95% confidence interval: 50.3% – 71.0%) with the remaining variation being attributable to unique environmental factors.
In this study of Australian twins, genetic factors were shown to be of major importance in IPD, with a heritability of 62%.
This PDF is available to Subscribers Only