May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Prevalence and Systemic Associations of Retinopathy in Individuals Without Diabetes
Author Affiliations & Notes
  • T.Y. Wong
    Centre Eye Research Australia, University of Melbourne, Melbourne, Australia
    Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore
  • E. Barr
    International Diabetes Institute, Melbourne, Australia
  • R.J. Tapp
    International Diabetes Institute, Melbourne, Australia
  • C.A. Harper
    Centre Eye Research Australia, University of Melbourne, Melbourne, Australia
  • H.R. Taylor
    Centre Eye Research Australia, University of Melbourne, Melbourne, Australia
  • P.Z. Zimmet
    International Diabetes Institute, Melbourne, Australia
  • J.E. Shaw
    International Diabetes Institute, Melbourne, Australia
  • Footnotes
    Commercial Relationships  T.Y. Wong, None; E. Barr, None; R.J. Tapp, None; C.A. Harper, None; H.R. Taylor, None; P.Z. Zimmet, None; J.E. Shaw, None.
  • Footnotes
    Support  Sylvia and Charles Viertel Clinical Investigator Award and the Biomedical Research Council Singapore
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1162. doi:
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      T.Y. Wong, E. Barr, R.J. Tapp, C.A. Harper, H.R. Taylor, P.Z. Zimmet, J.E. Shaw; Prevalence and Systemic Associations of Retinopathy in Individuals Without Diabetes . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1162.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To describe the prevalence of retinopathy and its association with systemic diseases in individuals without diabetes Methods: The Australian Diabetes Obesity and Lifestyle (AusDiab) study is a population–based study of persons 25 years and older in 42 randomly selected areas of Australia. All participants had an interview and clinical examination. Retinal photographs were taken of all participants diagnosed to have diabetes based on self–report and oral glucose tolerance test), impaired glucose tolerance and impaired fasting glucose, and a random sample of participants with normal glucose tolerance. Photographs were graded for presence and severity of retinopathy based on standard criteria. Analysis for this study was confined to persons without diabetes. Results: Retinopathy was present in 7.3% of the 890 participants with impaired glucose tolerance, 2.9% of the 137 with impaired fasting glucose and 5.8% of the 415 with normal glucose tolerance. After adjusting for age, gender, glycated hemoglobin levels, systolic blood pressure, LDL–cholesterol, triglycerides, body mass index, cigarette smoking status and microalbuminuria, participants with retinopathy were four times as likely to have prevalent stroke (OR 4.14, 95% CI 1.73 – 9.90) and peripheral neuropathy (OR 3.81, 95% CI 1.65 – 8.82) as those without retinopathy. These associations were stronger among participants with impaired fasting glucose and impaired glucose tolerance than among participants with normal glucose tolerance. Retinopathy was not associated with prevalent coronary heart disease or peripheral vascular disease. Conclusions: Retinopathy signs are common in adult persons without diabetes. Its presence may indicate systemic diseases elsewhere in the body.

Keywords: clinical (human) or epidemiologic studies: outcomes/complications • diabetic retinopathy • diabetes 
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