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D. Kim, H. Choi, D.C. Pye; Central Corneal Thickness as a Risk Factor for Glaucomatous Damage in Normal–Tension Glaucoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1298.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine whether central corneal thickness (CCT) is related to the extent of glaucomatous damage at the initial examination of normal–tension glaucoma (NTG) patients. Methods: Seventy–five eyes of 75 NTG patients showing localized retinal nerve fiber layer (RNFL) defects and corresponding early or moderate visual field defects were selected for this study. All participants underwent refraction, Goldmann applanation tonometry, CCT and corneal curvature measurements, stereoscopic disc photography, RNFL photography, and automated perimetry. True intraocular pressure was calculated using the Orssengo and Pye algorithm. Each patient’s age, CCT, true intraocular pressure, spherical equivalent of refraction, approximation of the RNFL defect to the fovea (Angle α), circumferential width of the RNFL defects (Angle ß), horizontal and vertical cup–to–disc ratios, and visual field data were analyzed. Results: In univariate and multivariate analyses, CCT was significantly associated with Angle α (P = .026), Angle ß (P = .042), and horizontal and vertical cup–to–disc ratios (P = .007 and .011, respectively). For a decrease of 10 µm of CCT, Angle α decreased by 1.50 degrees, Angle ß increased by 1.34 degrees, horizontal cup–to–disc ratio increased by 0.015, and vertical cup–to–disc ratio increased by 0.013, respectively.Conclusions:CCT is a powerful clinical factor in determining the extent of glaucomatous structural damage at the initial examination of NTG patients. CCT should be taken into account when assessing risk for progression of glaucomatous damage in NTG patients.
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