May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Intravitreal Ketorolac: Evaluation of Retinal Toxicity
Author Affiliations & Notes
  • H. Wafapoor
    Ophthalmology, University of Mississippi Medical Center, Jackson, MS
    Ophthalmology, VA Medical Center, Jackson, MS
  • J. McCluskey
    Ophthalmology, VA Medical Center, Jackson, MS
  • J.J. Brown
    Ophthalmology, University of Mississippi Medical Center, Jackson, MS
  • C.J. Chen
    Ophthalmology, University of Mississippi Medical Center, Jackson, MS
  • M.L. Palmer
    Ophthalmology, VA Medical Center, Jackson, MS
  • Footnotes
    Commercial Relationships  H. Wafapoor, None; J. McCluskey, None; J.J. Brown, None; C.J. Chen, None; M.L. Palmer, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 1457. doi:
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      H. Wafapoor, J. McCluskey, J.J. Brown, C.J. Chen, M.L. Palmer; Intravitreal Ketorolac: Evaluation of Retinal Toxicity . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1457.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the ocular toxicity of intravitreally injected ketorolac, a non–steroidal anti–inflammatory drug. Methods: Ketorolac was injected into the midvitreous cavity of 16 eyes of New Zealand white rabbits at concentrations of 10 micrograms (mcg) in 3 eyes, 50 mcg (6 eyes), 100 mcg (6 eyes), 1000 mcg (1 eye). The untreated eye served as a control. The volume injected was 0.1 milliliter. Prior to injection, a baseline examination was performed using indirect ophthalmoscopy and electroretinography (ERG). Following injection, the rabbits were clinically examined daily. ERG was repeated prior to enucleation. The rabbits were sacrificed at either 1 or 3 days postinjection, and the eyes underwent light and electron microscopy examinations. Results:No evidence of retinal toxicity was seen in eyes injected with 10 mcg and 50 mcg of ketorolac. No vitreous reaction was seen at any of the drug concentrations. ERG showed a normal b–wave amplitude in dark and light adaptation. Histopathological sections showed mild disorganization of the retina at 1000 mcg dosage. Conclusions: Intravitreal doses of ketorolac at 10 mcg and 50 mcg are nontoxic to rabbit eyes. Intravitreal dosage of 1000 mcg proved to be toxic to the retina.

Keywords: drug toxicity/drug effects • retina • inflammation 
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