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J. Nair Sahni, A. MacKay, P. Stanga, M. Brown, I. Grierson, D. Wong, S. Harding; Relationship Between Optical Coherence Tomography Characteristics and Multifocal Electroretinography in Patients With Subfoveal Choroidal Neovascularisation . Invest. Ophthalmol. Vis. Sci. 2005;46(13):1581.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the relationship between optical coherence tomography (OCT) and multifocal electroretinography (mfERG) in subfoveal predominantly classic choroidal neovascularisation (CNV) secondary to age–related macular degeneration (AMD). Methods: Patients with subfoveal CNV secondary to AMD were prospectively recruited. All patients had: refraction protocol log MAR visual acuity (VA), mfERG, Stratus OCT (OCT3), slit lamp biomicroscopy and fluorescein angiography to characterise the CNV. 19 segment mfERGs (Roland Consult Retiscan system) stimulating the central 40° field were recorded and summarised by the P1 amplitude density and latency of three concentric rings. Five mm single horizontal line scan and fast macular OCT3 scans (model 3000, Zeiss–Humphrey, USA) passing through the fovea were analysed using the terminology presented by us at ARVO 2003 (IOVS 2003; 44: E–abstract #4867): neuro–retinal foveal thickness (NFT), bilaminar foveal thickness (BFT) and outer high reflectivity band thickness (OHRBT). Intra retinal fluid (IRF) was defined as well–defined intraretinal hyporeflective spaces separated by reflective septae at the fovea. Statistics: Linear correlation between variables was analysed using Pearson correlation coefficient. P values of ≤0.05 were taken to be significant. Results: 28 eyes of 28 patients were recruited. There was no significant correlation between the P1 amplitudes in any ring and VA, NFT or BFT and P1 latency and OCT measurements (p>0.05). The OHRBT was significantly thicker in eyes with reduced P1 amplitude (p=0.002). There were trend associations between OHRBT, VA and ring 1 P1 amplitude/latency. There was no difference in the mfERG between eyes with and without IRF. Conclusions: The P1 mfERG response is thought to originate in the cones and may include responses from the inner retina. Our results suggest that an increased OHRBT and associated retinal pigment epithelial dysfunction may cause neuroretinal dysfunction detectable as a reduced mfERG amplitude density. In this study mfERG responses were not associated with increased retinal thickness.
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