May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Change of Nerve Growth Factor After 01% Prednisolone Instillation in Dry Eye Syndrome Patients and Its Correlation With Clinical Parameters
Author Affiliations & Notes
  • I. Ryu
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of med, Seoul, Republic of Korea
  • H.K. Lee
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of med, Seoul, Republic of Korea
  • K.R. Seo
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of med, Seoul, Republic of Korea
  • E.K. Kim
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of med, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  I. Ryu, None; H.K. Lee, None; K.R. Seo, None; E.K. Kim, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2049. doi:
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      I. Ryu, H.K. Lee, K.R. Seo, E.K. Kim; Change of Nerve Growth Factor After 01% Prednisolone Instillation in Dry Eye Syndrome Patients and Its Correlation With Clinical Parameters . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2049.

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Abstract

Abstract: : Purpose: To evaluate the change of the tear nerve growth factor concentration after 0.1% prednisolone treatment in dry eye syndrome patients and its correlation with clinical parameters Methods: Patients with dry eye received 0.1% prednisolone and hyaluronic acid eye drops three times a day each on right and left eye respectively. After 2, 4 weeks after treatment, clinic visits were followed, and BUT, schirmer, IOP and symptom scale were measured on both eyes. And on every visits, by collecting tear from both eyes, concentrations of nerve growth factor were measured and impression cytology was performed. Results: Total of 17 patients enrolled the study, and their mean age was 49.9 years old. The initial tear NGF concentrations were 862.28 ± 144.58 pg/mL and 812.75 ± 124.24 pg/mL on right and left eye respectively. On day 14, concentration changed to 731.92 ± 128.51 pg/mL on right eye with a statistical significance with correlation of impression cytology. Clinical parameters such as BUT, schirmer, IOP didn’t show any significant changes during the treatment. But, the symptom scale decreased on day 14 and 28 on right eye with a statistical significance. Conclusions: 0.1% prednisolone eye drop treatment on dry eye patients decreased the concentration of nerve growth factor, and would be an effective treatment as it discontinues anti–inflammatory process in short period of time without serious complications.

Keywords: cornea: tears/tear film/dry eye • cytokines/chemokines 
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