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C.C. Skotnitsky, D.F. Sweeney, T.J. Naduvilath, P.R. Sankaridurg; The Incidence of Local and General Contact Lens Induced Papillary Conjunctivitis in Silicone Hydrogel Contact Lenses . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2064.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To describe the incidence of contact lens associated papillary conjunctivitis (CLPC) in subjects wearing low Dk and silicone hydrogel contact lenses (CL) extended wear (EW); and to determine the recurrence rate of CLPC in silicone hydrogel CL EW. Methods: In retrospective clinical trials at both Australia and India from 1993 to 2003, 1,894 subjects wore either low Dk hydrogel CL on a 6 night (N) or silicone hydrogel CL on either a 6 N or 30N EW schedule. The incidence of CLPC per 100 eye years (%) for each lens type was determined for first events only. CLPC was classified by location of papillae. Papillae confined to ≤ 2 areas of the tarsal conjunctiva were classified as local and papillae spread over more than 2 areas were classified as general. Fisher’s Exact Test assessed differences between the two groups. Results: The incidence of CLPC in low Dk CL wearers was 3.9 per 100 eye years (95% CI = 2.9 – 5.0) and in silicone hydrogel CL wearers 5.2 per 100 eye years (95% CI = 4.3 – 6.2). There was a significantly greater incidence of local CLPC events compared to general events in silicone hydrogel CL (3.6% vs. 0.7%, p<0.0001) and a significantly greater incidence of general CLPC in low Dk hydrogel CL compared to local CLPC events (3.4% vs. 1.7%, p=0.003). 63% of all eyes had a recurrence of CLPC. 28% of eyes with prior CLPC events recurred as a general event and 49% of eyes recurred as a local event with silicone hydrogel CL wear. Conclusions: The incidence of local CLPC is higher in silicone hydrogel CL wear than in low Dk CL wear. This difference in incidence between local and general CLPC events may be caused by different mechanisms. At least 60% of eyes will have a recurrence of a CLPC event with silicone hydrogel EW.
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