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S.S. Vismara, N. Amar, Y. Ounnoughène, J.F. Girmens, M. Paques, J.A. Sahel, C. Baudouin; Correlation Between Laser Flare Meter Values, HRT II and OCT 3 Imaging After Intravitreal Triamcinolone Injection in Macular Edema . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2573.
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Purpose: To evaluate the correspondence between ocular flare, retinal thickness measured with Optical Coherence Tomography 3 (OCT) and retinal mapping with Heidelberg Retinal Tomograph II (HRT), in patients with macular edema after intravitreal injection of triamcinolone. Methods: Fifteen patients (mean age 62±12.9 years) affected by macular edema received intravitreal injection of 4mg of triamcinolone and were prospectively investigated with laser flare meter (LFM) and imaging with OCT and HRT within 1 week of, at 3, 8, 30 and 90 days after injection. All patients had a complete clinical examination at every step and gave their informed consent for all procedures. Results: Mean flare values before injection were 16.53±5.4 photons/ms, after 3 days 25.0±7.6, after 8 days 19.8±3.9, at 1 and 3 months, 9.58±2.4 and 15.6±7.8, respectively. Mean values of the OCT curve dropped continuously after injection, from 570µm central macular thickness to 292µm after 3 days, 235µm at day 8 and 202µm after 1 month. A slight increase was observed at the third month, up to 221µm. Average edema–index of HRT showed a decrease after treatment until day 30, from 2.67 to 1.78, rising slowly within 3 months to 2.38. In some patients, HRT and flare values slightly increased at month 3, corresponding to a worsening of visual acuity and suggesting a relapse of macular edema. Conclusions: Intravitreal injection of triamcinolone was certainly responsible for the immediate breakdown of the blood aqueous barrier with important increase of flare values. After 3 days excellent correspondences between retinal thicknesses, edema index and LFM values were observed until day 30. Later on we noticed a slight elevation of measurements, more evident with flare and HRT values. Further long term studies will be necessary to assess the respective interest of the three techniques. It could be hypothesized that HRT and LFM might be early indicators for recurrence of macular edema after intravitreal injection of triamcinolone in macular edema.
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