May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Vascular Endothelial Growth Factor Gene C–634G Polymorphism Is Associated With Age–Related Macular Degeneration
Author Affiliations & Notes
  • I. Kawasaki
    Department of Ophthalmology,
    Saitama Medical School, Iruma, Japan
  • S. Yoneya
    Department of Ophthalmology,
    Saitama Medical School, Iruma, Japan
  • N. Takata
    Fourth Department of Medicine,
    Saitama Medical School, Iruma, Japan
  • P.L. Gehlbach
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD
  • T. Awata
    Fourth Department of Medicine,
    Saitama Medical School, Iruma, Japan
  • K. Mori
    Department of Ophthalmology,
    Saitama Medical School, Iruma, Japan
  • Footnotes
    Commercial Relationships  I. Kawasaki, None; S. Yoneya, None; N. Takata, None; P.L. Gehlbach, None; T. Awata, None; K. Mori, None.
  • Footnotes
    Support  NEI EY134020–04, JDRFI 10–2001–412, Alexander and Margaret Stewart, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3002. doi:
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      I. Kawasaki, S. Yoneya, N. Takata, P.L. Gehlbach, T. Awata, K. Mori; Vascular Endothelial Growth Factor Gene C–634G Polymorphism Is Associated With Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3002.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To examine the potential relationship of vascular endothelial growth factor (VEGF) gene polymorphisms and development of age–related macular degeneration (AMD) in a native Japanese population. Methods: Sixty–five patients with AMD and 96 control subjects without AMD were recruited for this study. All were unrelated Japanese individuals. Genomic DNA was extracted from peripheral blood of each individual. Two polymorphisms of VEGF gene; the C–634G and the C–2578A were analyzed using ABI prism 7000. Results: The CC, CG and GG genotypes of C–634G in AMD patients were 12.3%, 63.1% and 24.6%, respectively. In control individuals, The CC, CG and GG genotypes of C–634G were 22.9%, 43.8% and 33.3%, respectively. Genotype distribution of the C–634G polymorphism of VEGF gene was significantly different between AMD patients and control subjects (p =0.047), but that of the C–2578A polymorphism was not (p =0.074). Conclusions: These preliminary results suggest that the VEGF gene polymorphism may represent a possible genetic risk factor for AMD in the Japanese population, encouraging further recruitment of patients and control subjects.

Keywords: age-related macular degeneration • gene screening • growth factors/growth factor receptors 
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