May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Acquired Lenticular Metaplasia of Müller Cells in the Damaged Avian Retina
Author Affiliations & Notes
  • R.R. Dubielzig
    Pathobiological Sciences, University of Wisconsin, Madison, WI
  • C.J. Zeiss
    Section of Comparative Medicine, Yale Medical School, New Haven, CT
  • Footnotes
    Commercial Relationships  R.R. Dubielzig, None; C.J. Zeiss, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3194. doi:
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      R.R. Dubielzig, C.J. Zeiss; Acquired Lenticular Metaplasia of Müller Cells in the Damaged Avian Retina . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3194.

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Abstract

Abstract: : Purpose: To describe and characterize the phenominon of spontaneous lenticular metaplasia in damaged avian retinas. Methods: An archive of comparative ocular pathology (C.O.P.L.O.W.) was used to retrieve avian ocular specimens with retinal damage and lens–like differentiation in the atrophic and disorganized retina. All cases were stained with H & E and PAS. Four good examples were stained by immunohistchemistry for GFAP and crystallin alpha–A. Results: Ten examples were found out of 13,000+ total specimens (155 total avina specimens). Three owls, 2 parrots, and one each of a hawk, vulture, duck, and ostrich were affected. All cases had evidence of trauma or, possibly, congenital retinal disease. One or several foci in each affected retina shows localized areas where individual or clusters of cells are appear as large, round, and glassy pink with H&E, appearing as lens bladder cells. These foci are always within atrophic and disorganized retinal tissue. There is a strong + staining with GFAP in easily recognised Müller cells with weak + staining for crystalline alpha–A. As the Müler cell takes on a bladder cell–like phenotype the cytoplasm becomes strongly + for crystallin alpha–A and weak for GFAP. Conclusions: There is a body of literature documenting the formation of lentoids or lens–like phenotype in Müller cells by manipulation of cultured embryonic avian retina but there are no reports of this phenominon as a spontaneous occurence in dammaged mature avain retina until now.

Keywords: retinal degenerations: cell biology • retinal glia • protein structure/function 
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