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M. Dorigo, E. Midena, V. Maritan, E. Convento; Peripapillary Microperimetry in Glaucomatous Eyes . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3735.
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Purpose: To determine, in patients with ocular hypertension and glaucoma, the existence of peripapillary threshold reduction using microperimetry and to evaluate the association between peripapillary sensitivity and retinal nerve fiber layer (RNFL) thickness. Methods: Fourteen eyes affected by ocular hypertension, ninteen eyes affected by glaucoma and fourteen age–matched controls underwent: peripapillary sensitivity quantification with microperimetry (fundus–related microperimetry; MP1 Microperimeter, Nidek Technologies, Padova, Italy) using a standardized peripapillary grid. RNFL thickness was quantified, using optical coherence tomography (Stratus OCT, Carl Zeiss, Jena, Germany), in a ring exactly corresponding to microperimetry threshold quantification. Standard automatic perimetry was performed in all except control eyes. Results: Peripapillary threshold was 17.1 ± 4.1, 13.4 ± 6.7 and 8.9 ± 6.6 db in control, ocular hypertension and glaucomatous eyes respectively (p < .0001). Progressive significant (p<.001) reduction of RNFL thickness was documented in ocular hypertension and glaucomatous eyes compared to controls. Significant correlation (r= 0.75) was documented just in control and ocular hypertension eyes between RNFL thickness and corresponding peripapillary sensitivity. Individual patterns of sensiivity vs RNFL thickness were identified in the examined groups. Conclusions: Microperimetric exact quantification of peripapillary sensitivity may be used as a new functional parameter in the integrated morpho–functional evaluation of glaucomatous eyes.
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