May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Assessment of Retinal Funtion During Treatment With Sildenafil
Author Affiliations & Notes
  • R.C. Becker
    Dept of Strabismology & Neuro, University of Giessen, Giessen, Germany
  • E. Kirchner–Pauli
    Dept of Strabismology & Neuro, University of Giessen, Giessen, Germany
  • Footnotes
    Commercial Relationships  R.C. Becker, None; E. Kirchner–Pauli, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3920. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R.C. Becker, E. Kirchner–Pauli; Assessment of Retinal Funtion During Treatment With Sildenafil . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3920.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Sildenafil citrat (Viagra®) is mainly an inhibitor of phosphodiesterase type 5 (PDE5) in smooth muscle cells. Due to the fact that there is also an inhibitory effect on PDE 6 of retinal photoreceptors, ophthalmological side effects are possible. Aim of this study was to find out if there are any effects on retinal function measured with the Ganzfeld–ERG and the multifocal ERG (mfERG) during treatment with sildenafil. Methods: 16 eyes from 8 patients (mean age 37.0 ± 8.2 years) were examined before and 3 months after start of treatment with sildenafil (3x50mg/d oral dose; reason for treatment: pulmonary hypertension). With the Ganzfeld–ERG, the 5 (ISCEV)–standard responses (photopic and scotopic) were recorded and analysed. Concerning mfERG, the First–Order Kernel (FOK) was recorded and the responses obtained from five different concentric rings for amplitude (nV/deg2, voltage difference between first trough and first peak of the scaled template) and implicit time (ms) were summed. Statistics: Wilcoxon matched pairs signed rank test. Results: There were no statistically significant differences for the amplitudes and implicit–times of the a– and b–wave in the Ganzfeld–ERG for all responses (e.g. cone response: amplitude a–wave before/after 3 months 42.4/45.0µV, implicit time a–wave 14.1/13.3ms). Concerning mfERG, amplitudes were decreasing with increasing retinal eccentricity, while there were no statistically significant differences for all rings between measurements before and 3 months after start of treatment; median values for ring 1 (nV/deg2 , before/ 3 months after start of treatment) 106.5/ 108. There also were no statistically significant differences for the implicit times for all rings; ring 1 (ms): 35.7/ 35.4. Conclusions: Treatment with sildenafil did not show any statistically significant changes of Ganzfeld–ERG and mfERG suggesting that there are no negative effects of sildenafil at least concerning the photopic and scotopic responses of the retina in the first 3 months of therapy. Our results are particularly interesting because of the higher daily dose used for treatment of pulmonary hypertension compared to treatment of male erectile dysfunction.

Keywords: pharmacology • electrophysiology: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×