Purchase this article with an account.
K.T. Mitchell, L.S. Gilmore, J.C. Bradley, G.E. Meyerrose, W.T. Ratnoff; Fabry's Disease as a Cause of Sequential, Bilateral Central Retinal Artery Occlusions: A Case and Review . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4055.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose:To discuss a female carrier of Fabry’s who presented with sequential, bilateral central retinal artery occlusions. Methods: Case report and literature review. Discussion: Fabry's disease (angiokeratoma corporis diffusum) is an X–linked disease of glycosphingolipid metabolism. A deficiency in lysosomal enzyme Alpha–Galactosidase A causes incomplete lipid catabolism, which accumulate in the endothelial and smooth muscle cells of vessels, resulting in progressive ischemia and infarction. We are reporting a case of sequential, bilateral central retinal artery occlusion (CRAO) in a patient who is a carrier for Fabry's Disease. Although rare, this case underlines the importance of a thorough systemic evaluation in the workup of CRAO. Previous literature highlighting fabry’s disease as an etiology for central retinal artery occlusion will be reviewed.
This PDF is available to Subscribers Only