May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
A Method for Measurements of Higher Order Aberrations and Light Scatter in Human Eyes
Author Affiliations & Notes
  • M. Shahidi
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • Y. Yang
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • A.S. Rajagopalan
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • K.R. Alexander
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • G.A. Fishman
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • R. Zelkha
    Ophthalmology & Visual Sciences, University of Illinois, Chicago, IL
  • Footnotes
    Commercial Relationships  M. Shahidi, None; Y. Yang, None; A.S. Rajagopalan, None; K.R. Alexander, None; G.A. Fishman, None; R. Zelkha, None.
  • Footnotes
    Support  NIH grant EY14275
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4328. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. Shahidi, Y. Yang, A.S. Rajagopalan, K.R. Alexander, G.A. Fishman, R. Zelkha; A Method for Measurements of Higher Order Aberrations and Light Scatter in Human Eyes . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4328.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: Measurements of ocular aberrations and light scatter provide information on limitations imposed by the optics of the eye that affect visual performance and imaging of the retinal tissue. A method for measurements of higher order aberrations and light scatter was developed and validated by investigating age– and disease–related changes in the optical properties of human eyes. Methods: An optical system has been developed for the imaging of a laser slit projected on the retina which incorporates a Shack–Hartmann aberrometer. Higher order ocular aberrations were measured as the area under the point spread function derived from the Shack–Hartmann image. Combined ocular aberrations and light scatter were measured as the area under the line spread function derived from the laser slit image. An index for ocular light scatter was derived as the area under the line spread function derived from the deconvolved laser slit image based on the measured point spread function of the eye. Measurements were obtained in 20 visually normal control subjects (43 + 16 years) and 13 retinitis pigmentosa (RP) patients (41 + 12 years) with minimal or no clinically visible posterior subcapsular cataract. Results:Higher order ocular aberrations were linearly correlated with age in control subjects (R = 0.6; p = 0.01; N = 20). Combined ocular aberrations and light scatter measurements were also linearly correlated with age in control subjects (R = 0.7; p = 0.0002; N = 20) as were ocular light scatter measurements (R = 0.5; p = 0.01; N = 20). Combined ocular aberrations and light scatter measurements in RP patients were significantly larger than measurements obtained in control subjects (p = 0.004). Higher order ocular aberrations were greater in RP patients as compared to the control subjects (p = 0.05). Ocular light scatter was significantly greater in RP patients than in the control subjects (p = 0.005). Conclusions: A method was developed that provides objective and quantitative measurements of ocular higher order aberrations and light scatter. This method has potential for monitoring age– and disease–related changes in the optics of human eyes and establishing the contribution of optical factors to degradation of visual performance and retinal imaging resolution.

Keywords: image processing • optical properties • imaging/image analysis: clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×