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S.–C. Baek, Y.–H. Ohn, S.–M. Kang; Multifocal Electroretinograms In Amblyopic Patients . Invest. Ophthalmol. Vis. Sci. 2004;45(13):246.
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Purpose: To evaluate the effect of amblyopia on multifocal electroretinogram(mfERG). Methods: The mfERG was performed on eight monocular amblyopic patients(age ranged from 7 to 42) using VERISTM(EDI,San Mateo). Central 30 degrees of ocular fundus were stimulated by an array of 103 hexagonal elements for four minutes. The responses of six concentric rings(ring 1 to 6) radiating from the foveal center were averaged, and the latencies and amplitudes of the N1, P1 and N2 were compared with the findings of normal contralateral eyes. mfERG was recored again after improvement of vision on one patient(No. 3) who had occlusion treatment for six months. Results: There were no significant differences on N1, P1 and N2 latencies between normal contralateral and amblyopic eyes(p>0.05). However, P1 amplitudes of the amblyopic eyes were reduced significantly compared with normal contralateral eyes on ring 1(p<0.05). N1 and N2 amplitudes of the amblyopic eyes were also reduced, but not significant. After the successful occlusion treatment of No. 3 patient, responses of the amblyopic eye were improved but did not reached that of the normal eye. Conclusions: These results suggest that amblyopia may cause some changes on the mfERG responses, especially on amplitudes of the central retina. Further investigation is needed to determine whether this results are due to the physiologic change(s) of amblyopia itself or fixation instability during the test.
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