May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Visualizing vitreous body in the anterior chamber using 11–deoxycortisol after posterior capsule rupture in an animal model
Author Affiliations & Notes
  • Y. Ishii
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Y. Kaji
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • T. Hiraoka
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • F. Okamoto
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • M. Sato
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • B. Hu
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • N. Yamane
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • T. Oshika
    Dept Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships  Y. Ishii, None; Y. Kaji, None; T. Hiraoka, None; F. Okamoto, None; M. Sato, None; B. Hu, None; N. Yamane, None; T. Oshika, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 278. doi:
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    • Get Citation

      Y. Ishii, Y. Kaji, T. Hiraoka, F. Okamoto, M. Sato, B. Hu, N. Yamane, T. Oshika; Visualizing vitreous body in the anterior chamber using 11–deoxycortisol after posterior capsule rupture in an animal model . Invest. Ophthalmol. Vis. Sci. 2004;45(13):278.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To develop a new technique of visualizing the vitreous body prolapsed in the anterior chamber using 11–deoxycortisol. Methods: In rabbit eyes, a suspension of 11–deoxycortisol, a precursor of cortisol without steroid activity, was injected into the anterior chamber after intentionally creating posterior capsule rupture. Following gentle irrigation and aspiration, the vitreous body prolapsed in the anterior chamber was removed using an anterior vitrectomy cutter. In another rabbit eyes, the side effects of 11–deoxycoritosol were assessed for biomicroscopic appearance, intraocular pressure, corneal endothelial count, and microstructure of the corneal endothelium. Results: In the posterior capsule rupture model, the vitreous in the anterior chamber became clearly visible with 11–deoxycortisol white particles entrapped on its surface. The injection of 11–deoxycortisol facilitated complete removal of the vitreous body from the anterior chamber. In intact rabbit eyes, most of the injected 11–deoxycortisol disappeared from the anterior chamber by 12 hours after injection. The injection of 11–deoxycortisol induced no influence on intraocular pressure, corneal endothelial density, and microstructure of the corneal endothelium. Conclusions: Injection of 11–deoxycortisol in the anterior chamber was useful in visualizing the vitreous body without any significant side effects. This technique would reduce the intraoperative and postoperative complications of anterior vitrectomy after posterior capsule rupture.

Keywords: cataract • vitreous • drug toxicity/drug effects 
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