May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Comparison of High–Dose Botulinum Toxin Type B to Botulinum Toxin Type A in the Amelioration of Lateral Canthal Wrinkles
Author Affiliations & Notes
  • M.T. Hamilton
    Ophthalmology, Brooke Army Medical Center, San Antonio, TX
  • D.E. E. Holck
    Ophthalmology, Wilford Hall Medical Center, San Antonio, TX
  • S. Marshall
    Ophthalmology, Wilford Hall Medical Center, San Antonio, TX
  • J.A. Foster
    Ophthalmology, Ophthalmic Consultants of Ohio, Columbus, OH
  • K.E. Morgenstern
    Ophthalmology, West Virginia Universtiy Hospital, Morgantown, WV
  • S.M. Blaydon
    Ophthalmology, Brooke Army Medical Center, San Antonio, TX
  • S. Demartelaere
    Ophthalmology, Brooke Army Medical Center, San Antonio, TX
  • Footnotes
    Commercial Relationships  M.T. Hamilton, None; D.E.E. Holck, None; S. Marshall, None; J.A. Foster, Allergan C; K.E. Morgenstern, None; S.M. Blaydon, None; S. Demartelaere, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 29. doi:
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      M.T. Hamilton, D.E. E. Holck, S. Marshall, J.A. Foster, K.E. Morgenstern, S.M. Blaydon, S. Demartelaere; Comparison of High–Dose Botulinum Toxin Type B to Botulinum Toxin Type A in the Amelioration of Lateral Canthal Wrinkles . Invest. Ophthalmol. Vis. Sci. 2004;45(13):29.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare botulinum toxin Type A to Type B in the treatment of lateral canthal rhytids. Methods: In a double–masked fashion, 20 pateints received injections of 15 units botulinum A on one lateral canthal area and 2,250 units of botulinum B on the contralateral side. Daily photos were obtained to Day 8, and weekly photos thereafter. The photos were graded by masked reviewers for static and dynamic wrinkles. Results: Botulinum toxin B showed much earlier onset of action with a shorter duration of action than botulinum toxin A. Side effects were significantly greater with toxin Type B. Conclusions: Even at higher doses, botulinum toxin Type B offers more rapid onset but significantly shorter duration than Type A. Type B also appears to diffuse more than Type A.

Keywords: eyelid • anatomy • aging 
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