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J.A. Cardillo, F. Paganelli, L.A. Melo–Jr, L.A. Melo–Jr, M. Skaf, R.A. Costa, A.G. Oliveira, Brazilian Ocular Pharmacol & Pharmaceut Tech Res Grp; A Single Posterior Subtenon Triamcinolone Acetonide Injection for the Treatment of Post–Cataract Surgery Inflammation . Invest. Ophthalmol. Vis. Sci. 2004;45(13):291.
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Purpose: To evaluate the safety and antiinflammatory efficacy of a single subtenon triamcinolone acetonide injection in the eye after cataract surgery in comparison with steroid drops. Methods:A total of 150 eyes undergoing phacoemulsification and intraocular lens implantation were prospectively randomized into three groups: 50 patients treated with 1% prednisolone eye drops (group A), 50 patients treated with subtenon triamcinolone (group B), and 50 patients receiving vehicle drops only (group C). After surgery, patients were randomized to receive either (B) a posterior 40 mg triamcinolone acetonide subtenon injection, (A) 1% prednisolone acetate self–instilled into the treated eye, according to the following schedule: 1 drop 4 times daily (week 1); 3 times daily (week 2); 2 times daily (week 3); once daily (week 4) or (B) one vehicle administered to the eye on a similar schedule. All eyes in group A and C also received a sham posterior subtenon injection of a 1 ml balanced salt solution Results: Triamcinolone was shown to have antiinflammatory efficacy clinically equivalent to conventional 1% prednisolone eye drops in reducing intraocular inflammation, as measured by clinical methods. It was significantly more effective than the vehicle in reducing anterior chamber cells (P < 0.001) and flare (P < 0.001), conjunctival erythema (P < 0.001), ciliary flush (P < 0.001), photophobia (P < 0.001), and pain (P < 0.001). Triamcinolone was found to be as safe as the prednisolone in terms of adverse events, changes in visual acuity, intraocular pressure, and biomicroscopic and ophthalmoscopic variables. Conclusions: Posterior subtenon triamcinolone acetonide injection is a safe and effective approach to suppress postoperative inflammation after uncomplicated cataract surgery. There was no statistical difference between subtenon triamcinolone and 1% prednisolone drops in efficacy in reducing intraocular inflammation, as measured by clinical methods.
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