Purchase this article with an account.
M. Ayaki, H. Ogura, H. Nishihara, S. Yaguchi; Surface activation of acrylic intraocular lens by surfactants in ophthalmic solutions . Invest. Ophthalmol. Vis. Sci. 2004;45(13):328.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the surface activation of intraocular lens (IOL) by ophthalmic solutions used posoperatively. Methods: Measurement of contact angle and glistening experiment were carried out using acrylic IOL (MA30BA, Alcon laboratories) placed in culture well filled with ophthalmic solution. The glistenings was induced by 48 hours incubation in 40 degrees followed by 24 hours incubation in 25 degrees. The formation of glistenings was photographically documented and graded by 20 examiners in masked fashion. Ophthalmic solutions tested were diclofenac sodium (DiclodR, Wakamoto, Japan), bromfenac sodium (BronuckR, Senju, Japan), betamethasone phosphate (RinderonR, Shionogi, Japan), and dibekacin sulfate (PanimycinR, Meiji Seika, Japan). DiclodR and BronuckR contain polysorbate, and others not. We used three IOLs for each solution in contact angle measurement and nine IOLs in glistening experiment. Results: The contact angle was smallest in DiclodR (40 degrees) and BronuckR(48), and it increased as diluted. Those of RinderonR(69) and PanimycinR(72) were similar to that of distilled water(79) in all dilutions. Formation of glistenings was most prominent in DiclodR, and least in PanimycinR with statistical significance. BronuckR and RinderonR were almost same. Conclusion: The present results substantially supported our clinical investigation reported in ARVO 2003. Polysorbate or other components in ophthalmic solutions may associate with glistening formation. We should be aware of the long–term interaction of the biomaterials and the topical medications used for postoperative inflammation control, glaucoma, dry eye, allergy, or other chronic conditions.
This PDF is available to Subscribers Only