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Y. Katayama, H. Yanagawa, S. Kobayakawa, Y. Katayama, T. Tochikubo; Preventive Effect Of Posterior Capusule Opacification Of Opti–Edge Design Intraocular Lens . Invest. Ophthalmol. Vis. Sci. 2004;45(13):361.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:Intraocular lens(IOL) with a sharp shaped optical edge has been found to be useful for prevention of posterior capsule opacification (PCO). However there is a problem of edge–glare. To improve this issue, the OptiEdge IOL, with a round–shaped front end and sharp–shaped back end, is marketed commercially. In this study, we compared preventive effects on PCO by a difference of edge configuration. Methods:Japanese white rabbits were implanted 3 kinds of silicone IOLs. Samples of optical edge are asfollows; SI40NB (AMO, Round–Edge group) with a round–shaped front and back end, AQ310NV(CANON STAAR, Sharp–Edge group) with a sharp–shaped front and back end, ClariFlex (AMO,Opti–Edge group)with a round–shaped front end and sharp–shaped back end. After phacoemulsification under general anesthesia , each type of IOLs were implanted.Each samples were enucleated at three weeks aftert surgery. PCO area were analyzed by Miyake–Apple view, and histopathologically observed the migration of lens epithelial cell(LEC), fibrous cell and capsule bag bending build–up. Results:The average value of PCO area was as follows; 48.2±8.5% for RE group (N=5), 20.2±9.0% for SE group (N=5), 18.8±9.6% for OE group (N=5). The value of RE group was significantly large compared with other groups, however the difference between SE and OE is not significantly large. The result shows that the number of samples, prevented the migration of LEC , is, 0 for RE group, 4 for SE group, 4 for OE group (in 5 samples). In both SE and OE group, capsule bags bending build–up on the back end are in good condition. These results couldn’t confirm the difference of LEC migration to posterior capsule side, which caused by the difference of front edge shape. Conclusions:As the result shows, compared with the round edge, the sharp edge and the opti–edge are effective for PCO prevention, and also have almost same preventive effect to this issue. The result suggests that the OptiEdge IOL would be desirable for clinical usage from optical point of view.
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