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H. Ogura, M. Ayaki, H. Nishihara, S. Yaguchi; Inhibition of lens epithelial cell migration by acrylic intraocular lens: New evaluation method of optic edge sharpness with quantification of edge curvature. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):362.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: We reported finishing of posterior optics edge in acrylic intraocular lens (IOL) was associated with lens epithelial cell (LEC) migration and the formation of posterior capsule opacification (PCO) in the rabbit eyes (Ophthalmic Res, 2003). In the present investigation, we prepared experimental IOLs with quantified edge sharpness to confirm previous observations and attempt to standardize edge sharpness. Methods: The phacoemulsification and aspiration, and acrylic IOL insertion were performed in 12 rabbit eyes. We made three types of experimental IOLs with different sharpness in posterior optic edge, i.e., radius of curvature at the edge was 20, 10, and zero micron (exactly rectangular), respectively. Haptics angulation was 5 degrees. Slit–lamp microscopic observation was done at 1, 2 and 3 weeks postop, followed by euthanasia, removal of eyes, and pathological examination of the anterior segment including hematoxylin–eosin staining and toluidine–blue staining. The grade of migration and proliferation of LECs were scored and compared in masked fashion. Results: The average value of score indicated migration and proliferation between the edge and posterior capsule was greatest in 20 micron group (approx. 3.0), then 10 micron group (1.2), and least in zero micron group (0.5). Conclusions: Our results showed the radius of curvature at the edge could represent edge sharpness in acrylic IOL and this quantification might provide new method for evaluation of inhibitory effect on PCO by IOL.
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