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J.T. Landrum, R.A. Bone, Z. Dixon, V. Etienne–Levielle, M. Formosa, M. Saint–Louis; Influence of Lutein Dosage on Macular Pigment Response . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1290.
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Purpose: This study investigated the effect of lutein dose, over a 120 day (d) period, on the rate of increase in macular pigment optical density (MPOD). On a double–blind basis, subjects were assigned to 3 different dosage groups, or a placebo group. Doses were 5, 10 and 20 mg/d of lutein (as esters from marigolds). Methods: MPOD was measured twice per week in each subject by flicker photometry using a 1.5° stimulus. The table shows the average rates of increase in MPOD for each group (mAU = milli–absorbance unit). Results: The 20 mg group in row 4 was composed of 25 subjects below the age of 30 (row 5) and 14 subjects over 50 (row 6). By excluding the over 50 group, the dosage groups are reasonably age–matched. They indicate a general increase in MPOD response with dose. The 10 and 20 mg groups, but not the 5 mg group, differed significantly from the placebo group (p < 0.05, 1–sided t–test). For the two age groups taking 20 mg, there was a weaker MPOD response in the older group compared with the younger (p = 0.05). Column 5 shows that with increasing dose, an increasing number of eyes exhibited a positive MPOD response. Conclusions: We conclude that in the short term, 20 mg doses are effective at raising MPOD, but smaller doses may be of marginal value.
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