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J. Shen, D.M. O'Day; TEST OF AN ACCOMMODATIVE INTRAOCULAR LENS IN AN ex vivo SIMULATED ACCOMMODATION MODEL . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1725.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: The purpose of this study is to test the accommodation effect of an accommodative intraocular lens (IOL) by using cadaver animal eyes. Methods: A mechanical adjustable iris diaphragm was customized, with eight tweezers symmetrically attached to the leaves. Fresh animal cadaver eyes were dissected, so that the lenses with iris and ciliary muscle together were obtained. The ciliary muscle was clamped to the eight tweezers symmetrically, so that by adjusting the diameter of the diaphragm, we could induce the diameter change to the ciliary muscle, thus simulate the accommodation effect in an ex vivo model. Capsulorrhexis was performed on the anterior surface of the clamped pig eye lens. Lens content was removed. The accommodative IOL was implanted into the lens capsule. The movement of the IOL with the ciliary muscle diameter change was studied. The diopter change of the accommodative IOL was measured with an autorefractor. Results:With the mechanically induced ciliary muscle movement, up to 0.5 mm diameter change of IOL was observed. Ocular refraction difference of 0.25 to 5 diopter change was recorded with the autorefractor. Conclusions: Our designed accommodative IOL could be implanted into the lens capsule and produce accommodation effect in the ex vivo model. CR:P Support: The Whitaker Foundation Biomedical Engineering Grant.
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