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Y. Otaka, N. Horio, M. Horiguchi, Y. Shimada; Intravitreal Injection of Triamcinolone Attenuates Anterior Inflammation after Combined Surgery of Vitrectomy and Phacoemulcification with Intraocular Lens Implantation in Eyes with Idiopathic Epiretinal Membrane . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1933.
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Purpose: To determine the effect of intravitreal injection of triamcinolone acetonide on anterior inflammation after combined surgery of vitrectomy and phacoemulcification with intraocular lens implantation (IOL surgery) in eyes with idiopathic epiretinal membrane (ERM). Methods: 21 eyes of 20 patients with an ERM and no other eye disease were studied prospectively. The patients were randomly divided into Group A (11 eyes of 10 patients)who underwent ERM peeling without intravitreal triamcinolone injection, and Group B (10 eyes of 10 patients)with intravitreal injection of triamcinolone (1.6 mg/0.2ml). Anterior chamber inflammation was measured using a laser flare cell meter at 1, 3, 5, 7, 14 day postoperatively. Results: The anterior chamber flare was significantly lower in Group B than in Group A at 3, 5, 7 day postoperatively with the maximum difference at 5 day (16.1 ± 4.7 pc/ms vs. 11.4 ± 2.7 pc/ms, Group A vs. Group B, P<0.01). There was no difference in anterior flare at 1 or 14 day postoperatively. The cell count or improvement of visual acuity was not different between the 2 groups. Conclusions: Our data demonstrated that intravitreal injection of triamcinolone acetonide attenuates anterior inflammation after vitrectomy with IOL surgery in eyes with ERM although it is a short–term effect within 1 week. This method may be useful to reduce the postoperative complication due to anterior inflammation.
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