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M.–J. Park, S.–C. Baek, Y.–H. Ohn, T.–K. Park; Multifocal Electroretinographic Findings after Intravitreal Injection of Triamcinolone Acetonide on Macular Edema. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1940.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate macular function changes of central retinal vein occlusion (CRVO) and diabetic maculopathy after intravitreal injection of triamcinolone using multifocal electroretinogram (mfERG). Methods: Seven eyes of seven patients were included in this study. Four eyes were CRVO, three diabetic maculopathy. A intravitreal injection of 4 mg triamcinolone was carried out. The mfERG was performed with VERIS system (EDI, San Mateo) before intravitreal injection and after one month. Central 30 degrees of ocular fundus were stimulated by an array of 103 hexagonal elements for four minutes. The responses of two concentric rings (ring 1 and 2) radiating from the foveal center were averaged, and the amplitudes and latencies of the N1, P1 and N2 were compared between before and after intravitreal injection of triamcinolone acetonide. Those results were compared with visual acuity and fluorescein angiographic findings. Results: Average P1 amplitude of ring 1 was 27.17 nV, ring 2 was 17.82 nV before injection, 27.18 nV and 18.51 nV after injection (P>0.05). Average N1 latency of ring 1 was 16.42 ms, ring 2 was 17.85 ms before injection, 14.72 ms and 14.64 ms after injection (P>0.05). The visual acuity and fluorescein angiographic findings were improved after injection. Intraocular pressure elevation was seen in two eyes and treated with topical antiglaucoma agents. There were no complications such as cataract, retinal detachment or endophthalmitis. Conclusions: Responses of mfERG were improved after intravitreal injection of triamcinolone, although these results were not significant. The mfERG could be an useful tool to assess the macular function changes after intravitreal injection of triamcinolone on macular edema due to CRVO and diabetic maculopathy. Long term follow–up is needed to determine how these results change.
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