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M.K. Tran, A. Jain, M. Abbago, D. Sarraf, S.D. Schwartz; Detection of Retinal Crystals by Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2372.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the clinical utility of Optical Coherence Tomography (OCT) in the diagnosis and management of various crystalline retinopathies. Methods: Four patients with various crystalline retinopathies including canthaxanthine, Tamoxifen, talc, and West African Crystalline Maculopathy underwent OCT analysis of the macula to assess the localization and associated complication of the crystals. Results: Detection of the crystals with OCT analysis was not consistently diagnostic. The crystals appeared to present as hyperreflective deposits localized to the inner retina in each of the four cases consistent with previous clinical and histopathological studies. The crystals were unassociated with anatomical or structural damage to the fovea. This information was particularly useful in the Tamoxifen case in which there was a high suspicion of macular edema upon clinical and angiographic evaluation. Conclusions: OCT analysis may demonstrate hyperreflective inner retinal deposits in various crystalline retinopathies but without diagnostic confidence. OCT may be more useful to exclude associated anatomical changes, such as macular edema, which may complicate certain crystalline retinopathies.
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