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Y.K. Ghosh, A.V. Reginald, S. Banerjee, S. Dhingra, A.K. Tyagi, G.Y. H. Lip; A comparison of plasma and vitreous levels of angiogenic factors [Vascular Endothelial Growth Factor, soluble VEGF receptor, Angiopoietin 1 & 2, and angiopoietin receptor TIE 2] in proliferative diabetic retinopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2498.
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Purpose: To compare plasma and vitreous levels of angiogenic factors [Vascular Endothelial Growth Factor (VEGF, in index of angiogenesis), soluble VEGF receptor (sFlt–1), Angiopoietin 1 & 2 (Ang–1, Ang–2) and soluble angiopoietin receptor TIE 2 (tie–2)] in patients with proliferative diabetic retinopathy undergoing vitrectomy. Methods: 23 patients (18 male), mean age 51 years (range 25 to 72) with proliferative retinopathy secondary to diabetes and with no previous vitreo–retinal surgery were studied. Plasma and undiluted vitreous samples were obtained on the day of surgery. Plasma and vitreous levels of VEGF, sFLT–1, Ang 1 and 2 and tie 2 were assayed using ELISA.
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