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A. Kozaki, N. Komoto, Y. Ishii, T. Maeda, Y. Inoue; Proptosis in Japanese patients with Dysthyroid Ophthalmopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2717.
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Purpose: To study how the severity of proptosis would influence patients' clinical characteristics in Japanese patients with dysthyroid ophthalmopathy. Methods: A total of 10,932 patients (21,863 eyes, 8,692 female, 2,240 male, mean age of 39.9 years ranging between 5 and 87) were evaluated for proptosis using a Hertel exophtalmometer,during the ten–year period between 1993 and 2002. MRI or CT scan analized enlargement of the extraocular muscle causing proptosis. The severity of eye changes was scored by the classification previously published by Inoue et al(Orbit.vol1.1982 ). Data were analyzed by multiple regression. Results: Teenagers showed severer proptosis which eventually decreased over time by age (p<.001). Men showed severer proptosis than women (p<.001). Enlargement of the extraocular muscle was observed more often in the older patients and also in men. The severity of eyelid fissure, eyelid swelling, diplopia and optic neuropathy showed positive correlation with the severity of proptosis. Female to male ratio was about four to one in all, but this ratio was one to one in 175 patients (1.6%) who showed proptosis more than 25mm. Conclusions: The degree of proptosis correlates well to the severity of ocular manifestations.
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