May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Intraocular Light Stimulation by Intraocular Vision Prostheses in Animal Experiments – First Results
Author Affiliations & Notes
  • G.F. Roessler
    Ophthalmology, Technical University Aachen, Aachen, Germany
    Ophthalmology, University of Cologne, Cologne, Germany
  • N.M. Alteheld
    Ophthalmology, Technical University Aachen, Aachen, Germany
    Ophthalmology, University of Cologne, Cologne, Germany
  • M.A. Vobig
    Ophthalmology, Technical University Aachen, Aachen, Germany
    Ophthalmology, University of Cologne, Cologne, Germany
  • J. Huth
    Ophthalmology, Technical University Aachen, Aachen, Germany
    Ophthalmology, University of Cologne, Cologne, Germany
  • P. Walter
    Ophthalmology, Technical University Aachen, Aachen, Germany
    Ophthalmology, University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships  G.F. Roessler, None; N.M. Alteheld, None; M.A. Vobig, None; J. Huth, None; P. Walter, None.
  • Footnotes
    Support  DFG: HE 840/8–1
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 2932. doi:
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      G.F. Roessler, N.M. Alteheld, M.A. Vobig, J. Huth, P. Walter; Intraocular Light Stimulation by Intraocular Vision Prostheses in Animal Experiments – First Results . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2932.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: The IOVA research group developed an intraocular microdisplay to be implanted in eyes affected by heavy injuries or severe inflammations where penetrating keratoplasty failed to restore sight, so surgical recovering of the anterior segment is not required anymore. First experiments included the implantation of LEDs being incapsulated in intaocular lenses (IOL–LED) to prove tolerability and function of intraocular displays. Methods: The IOL–LEDs were implanted into the sulcus or the capsular bag of the removed natural rabbit lens. In the meantime energy supply occurs wireless whereas first experiments used cables for electrical power supply. For proving biocompatibility and function of the encapsulated displays several examinations including funduscopy, electroretinogram (ERG) and visually evoked potentials (VEP) as well as histological examinitions were performed. Results: Retinal stimulation by IOL–LEDs did not cause severe complications. Cortical potentials as well as retinal responses in ERG could be elicited by LED–stimulation. Activation of the intraocular display did not cause any morphological or histological damages on the retina. Conclusions: The evidence of cortical activation and biocompatibility proved the general feasibility of the IOVA approach

Keywords: keratoprostheses • trachoma • anterior segment 
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