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C. Jahn, H. Wüstemeyer, C. Brinkmann, S. Trautmann, A. Mößner, U. Schnurrbusch, S. Wolf; Macular pigment density subject to different stages of age–related maculopathy . Invest. Ophthalmol. Vis. Sci. 2004;45(13):2968.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Macular pigment (MP) is attempt to have a protective role in the development and progression of age–related maculopathy (ARM). We present results of measurements of macular pigment density (MPD) in patients with ARM at different stages with a modified confocal scanning laser ophthalmoscope (HRA, Heidelberg Engineering, Heidelberg, Germany). Methods: Patients with ARM were recruited for this study. The severity of ARM was categorized into 3 groups according to the Rotterdam Study classification (stage 1–3). The staging depended upon the size and shape of drusen, presence of pigmentary abnormalities and atrophic or neovascular AMD changes. Macular pigment density maps were calculated from autofluorescence images recorded with a modified HRA at 488 nm and 514 nm. MPD was quantified from the MPD maps within 2 degrees around the center of the fovea. As controls a group of 155 healthy subjects were examined. Results: We included 237 patients with ARM into this study. There were significant differences between MPD in ARM patients as compared with healthy controls (ARM: MPD = 0,195±0,075 D.U.; controls: MPD = 0,214±0,077 D.U.; p < 0.05). Subgroup analysis revealed significant differences between patients with ARM stage 1 (0,186±0,074 D.U.,; n=109) and patients with ARM stage 3 (0,191±0,079 D.U.; n=65) and healthy subjects. No differences were found for patients with ARM stage 2 (0,213±0,068D.U.; n=63) Conclusions: Our study showed significant differences of MPD between healthy subjects and the patients with minimal (stage 1) and severe (stage 3) ARM pathologies. Further longitudinal studies are necessary to compare the incidence of AMD in eyes with high and low MPD in order to provide a definite evidence of the influence of MPD on the progression of AMD.
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