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N. Benhamou, O. Segal, A. Kaplan–Messas, B. Serebryany, P. Massin, A. Gaudric, I. Avni; Comparison in healthy patients of macular thickness measurement with optical coherence tomography 3 and retinal thickness analyzer . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3008.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: to compare the retinal thickness in healthy subject measured with optical coherence tomography 3 (OCT3) and with the retinal thickness analyzer (RTA) Methods: Retinal thickness was measured with both tools in 72 eyes of 47 healthy patients (24 women and 23 men), aged 19 to 77 years. Retinal thickness was measured automatically with OCT mapping software. In order to properly compare the results, a software that display the RTA results in a similar map in term of area than the OCT (in 9 ETDRS–type area) was developed for the RTA Results: Mean retinal thickness in the central area 1000µm in diameter was 144µm +/–16 (113–183) for the RTA and 196µm +/–17 (168–236) for the OCT3. RTA data were similar than these of the literature. Measurements obtain with OCT3 were superior of 15% from those obtain in OCT2 in all 9 ETDRS area (196 vs 170 µm for the central 1000µm). A correlation was found between the data provided by OCT and RTA (r=0.551, P<0.001). In all 74 eyes, the automatic measurement software of OCT 3 mistaken and took into accounts the photoreceptor layer as the outer boundary of the retina instead of the retinal pigment epithelium. Thus, the retinal measurement provided by OCT3 did not include the photoreceptor layer, leading to underestimation of the macular thickness. Men tend to have central macular and foveal thickness thicker than women in both tools, but the difference was significant only with the OCT (P=0.001). For both methods, no relation in macular thickness was found with age Conclusions: Both methods provide very different macular measurement in term of absolute value. Values obtain with OCT 3 were superior from 15% of those obtain with OCT2. Central area (1000µm) should be considered thickened above 180µm with RTA, above 230µm with OCT3 and above 210µm with OCT 2. Automatic measurement software of OCT 3 systematically underestimated retinal thickness by taking into accounts the photoreceptor layer instead of the RPE as the outer boundary of the retina. RTA presents some advantages over OCT: shorter acquisition time, higher number of measurements homogeneously distributed in the macular area and results displayed in 3D mapping. In the other hand, OCT 3 provides better intra retinal resolution and is less sensible to cataract opacities
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