May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Choroidal neovascularisation screening using non–stereo digital fundus photograph
Author Affiliations & Notes
  • S. Jain
    Ophthalmology, Retina Research Unit, Kings College Hospital, London, United Kingdom
  • S. Hamada
    Ophthalmology, Retina Research Unit, Kings College Hospital, London, United Kingdom
  • W.L. Membrey
    Ophthalmology, Retina Research Unit, Kings College Hospital, London, United Kingdom
  • V. Chong
    Ophthalmology, Retina Research Unit, Kings College Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  S. Jain, None; S. Hamada, None; W.L. Membrey, None; V. Chong, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3073. doi:
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      S. Jain, S. Hamada, W.L. Membrey, V. Chong; Choroidal neovascularisation screening using non–stereo digital fundus photograph . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3073.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Choroidal neovascularisation (CNV) is the leading cause of blindness in the developed world. Significant visual loss can occur in the early phase of the disease. The time delay between first presentation to a health care professional to the treating retinal specialists should be minimized. We investigate a low cost method using non–stereo digital fundus photograph as a screening tool for CNV Methods: 198 randomized fundus photographs were presented to two independent ophthalmic interns. No further information was given to the graders. These were graded by two graders into one of the three categories, normal, dry age–related maculopathy (ARM) and CNV. Their results were then compared to the actual outcome of each of these patients after investigations and evaluation in the macular clinic Results:There were 66 normal images, 57 images of patients with ARM and 56 images of patients with CNV. Another 19 images were duplicated to check for intraobserver reliability. The intraobserver Kappa were 0.75 and 0.91 for grader 1 and 2 respectively. The interobserver Kappa was 0.54. The mean sensitivity and specificity for the identification of CNV was 85.7% and 64.9%. Most false negatives were those with small classic CNV which are difficult to identify using non–stereo images alone, however, the elevation are more likely to be seen with stereo images. Conclusions: Non–stereo digital fundus photograph is a reasonable screening tool for CNV, however, stereo fundus photographs might be better.

Keywords: age–related macular degeneration • choroid: neovascularization • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology 
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