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N.E. Gross; The Natural Course of Neovascularization in the Fellow Eye of Patients with Unilateral Retinal Angiomatous Proliferation . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3091.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To characterize the natural course of the neovascular process that develops in the uninvolved fellow eyes of patients with unilateral,symptomatic retinal angiomatous proliferation (RAP), a form of neovascular age–related macular degeneration (AMD). Methods:This was a retrospective case series involving 77 patients with RAP in one eye (77 eyes) some of whom went on to develop neovascular AMD in the fellow eye. Clinical biomicroscopic examination, fluorescein angiography, and indocyanine green angiography were used to evaluate patients. Results:Neovascular AMD developed in the fellow eye of 52 patients (68%) over a mean follow–up 26 months. The neovascularization was characterized in the following manner: type of CNV, development of RAP and its stage, visual acuity of the fellow eye and risk of CNV development over time. Conclusions: Patients with unilateral, symptomatic RAP lesions frequently go on to develop neovascular AMD in the fellow previously uninvolved eye. Characterization of the natural course of the neovascular process may help in the prognostic counseling, management, and treatment of patients with this disorder.
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