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K. Yamada, M. Osako, T. Agawa, M. Miura, K. Tachibana, M. Usui; Detectability of glaucoma by scanning laser polarimetry using variable corneal compensator compared with fixed corneal compensator . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3314.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the detectability of glaucoma using scanning laser polarimetry with variable corneal compensator (GDx VCC, Laser diagnostic Technologies). Methods:We studied 57 eyes of 57 glaucoma patients and 25 eyes of 25 normal subjects. The mean age was 62.4 ± 12.0 years in glaucoma group and 58.2 ± 11.0 years in normal group, with no significant difference (t–test, p=.14). Each eye was tested with GDx VCC and scanning laser polarimetry with fixed corneal compensator (GDx FCC). Program 24–2 of the Humphrey Field Analyzer (HFA) was performed on all subjects. GDx parameters of TSNIT Average (TA), Superior Average (SA), Inferior Average (IA), TSNIT Standard Deviation (TSD), and Nerve Fiber Indicator (NFI) were calculated using built–in programs of GDx VCC and GDx FCC. Any parameter outside normal limit (p<.05), or NFI greater than 50 in GDx VCC, or greater than 60 in GDx FCC was defined as abnormal. Sensitivity and specificity of each GDx parameter were evaluated using chi–square test. Results:In GDx FCC, although TSD showed 43.9% sensitivity and 96.0% specificity with significant relation (p<.001), no significant relation was found for TA, SA, IA, and NFI. In GDx VCC, all parameters showed significant relation, with 49.1–75.4% sensitivity and 92.0–100% specificity (p<.0001). If a case with any parameter outside the normal limit (p<.05) was defined as abnormal, GDx VCC showed 89.7% sensitivity and 92.0% specificity with significant relation (p<.001), whereas GDx FCC showed no significant relation. In early glaucoma cases (32 eyes) with mean deviation (MD) greater than –5.0 dB, all parameters of GDx VCC showed significant relations (p<.001), whereas none of the parameters of GDx FCC was significantly related. Conclusions: The efficacy of glaucoma detectability improves markedly using GDx VCC compared with GDx FCC.
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