Purchase this article with an account.
M.S. Kook, J. Jung, J. Hwang, H. Hong, J. Kim; Discriminating ability of Scanning Laser Polarimetry with Variable Corneal Compensation (GDx–VCC) in Normal and Glaucomatous Eyes in Korean population . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3322.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To study the ability of GDx–VCC to discriminate between healthy and glaucomatous eyes with different degrees of visual field abnormality. Methods: 32 healthy and 52 age–matched glaucomatous eyes over 40 years of age were examined with GDx–VCC. There were 30 eyes in the early glaucomatous stage (Humphrey mean deviation = –3.23 dB) and 22 eyes in the moderate to advanced stage (Humphrey mean deviation = –10.13 dB) Areas under the receiver operating characteristic (ROC) curve for discriminating between the healthy and each of glaucomatous groups were obtained. Results:The areas under the ROC curve improved with GDx–VCC compared with the published data based on scanning laser polarimeter with Fixed Corneal Compensator (GDx–NFA). The parameter with which the area under the ROC curve showed the best was NFI(neural–network based summary parameter). Its sensitivity and specificity were 96.2% and 84.4%, respectively, in the eyes at early glaucomatous stage based on cut–off value of 21. In the eyes at moderate to advanced stage, NFI showed its sensitivity and specificity of 100% and 82.9%, respecitively, at cut–off value of 21.The areas under the ROC curve of GDx–VCC thickness parameters (0.85– 0.93) were comparable to or greater than those of ratio parameters (0.76–0.80). Conclusions:GDx–VCC showed improved ability to discriminate between healthy and glaucomatous eyes at different stages of glaucoma, especially based on thickness parameters. NFI was found to be the best discriminating parameter in both stages of severity.
This PDF is available to Subscribers Only