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R.M. Vessani, I.R. A. Elias, M.Q. Alves, L. Trancoso, R. Susanna, Jr.; RNFL thickness measured by OCT 3 and central corneal thickness in ocular hypertensive patients . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3407.
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Purpose: to evaluate and correlate mean peripapillary RNFL with central corneal thickness measurements in ocular hypertensive patients . Methods:Prospective consecutive study with 65 eyes of 65 subjects (29 ocular hypertensive patients and 35 normal subjects). Peripapillary RNFL thickness and optic nerve head protocols were performed with optical coherence tomography (OCT 3, Carl Zeiss Meditec, Dublin, CA, USA) in all subjects. Ocular hypertension patients had central corneal thickness measurements by ultrasonic pachymetry (Storz UPC1000, Storz, St. Louis, MO, USA) and were divided into two subgroups based on their results( group I: CCT < 540µm and group II :CCT > 540µm ). Results: No significant difference in age, race or sex was found between OHT patients and normal controls and nor between the OHT subgroups. From an overall optic disc area of 2.13 mm2, mean RNFL thickness in ocular hypertensive patients (mean ± standard error of the mean) was 98.27 ± 2.53 µm and 106.50 ± 2.28 µm in normal controls. The difference between groups of 8.23 ± 3.43 µm was significant (P = 0.02, analysis of covariance; 95% confidence interval [CI]: 1.37 to 15.09). From an overall optic disc area of 2.08 mm2, mean RNFL thickness (mean ± standard error of the mean) in ocular hypertensive patients of group I was 92.98 ± 5.55 µm and 101.77 ± 4.08 µm in ocular hypertensive patients of group II. The difference between groups of 8.79 ± 7.4 µm was significant (P = 0.03, analysis of covariance; 95% confidence interval [CI]: 24.06 to – 6.49). Conclusion: Ocular hypertensive patients with corneas thinner than the normal mean value have lower peripapillary RNFL thickness measurements by OCT 3 compared to ocular hypertensive patients with thicker corneas.
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