May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Study of drug effects of dihydropyridine Ca2+ antagonists on retinal degeneration in Royal College Surgeons rat
Author Affiliations & Notes
  • H. Yamazaki
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • H. Ohguro
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • I. Ohguro
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • K. Mamiya
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • F. Ishikawa
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • T. Metoki
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • Y. Miyagawa
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • Y. Takano
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • T. Ito
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • M. Nakazawa
    Ophthalmology, Hirosaki Univ Sch of Medicine, Hirosaki, Japan
  • Footnotes
    Commercial Relationships  H. Yamazaki, None; H. Ohguro, None; I. Ohguro, None; K. Mamiya, None; F. Ishikawa, None; T. Metoki, None; Y. Miyagawa, None; Y. Takano, None; T. Ito, None; M. Nakazawa, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 3584. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      H. Yamazaki, H. Ohguro, I. Ohguro, K. Mamiya, F. Ishikawa, T. Metoki, Y. Miyagawa, Y. Takano, T. Ito, M. Nakazawa; Study of drug effects of dihydropyridine Ca2+ antagonists on retinal degeneration in Royal College Surgeons rat . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3584.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:The Royal College of Surgeons (RCS) rat is the most extensively studied animal model for understanding the molecular pathology of inherited retinal degeneration, such as retinitis pigmentosa (RP). In our recent study, we have found that some types of Ca2+ antagonists may potentially have preservation effects on RCS retinal degeneration. Here, in order to further study drug effects of several types dihydropyridine (DHP) (L–type, N–type, P/Q–type and R–type) of Ca2+ antagonist, which are most frequently used for treatment of hypertension in our clinic, on the retinal degeneration of RCS rats. Methods: Several types of DHP Ca2+ antagonists, nicardipine, nilvadipine, nifedipine, cilnidipine, and amlodipine were intraperitoneal administrated and thereafter retinal morphology and functions were analyzed. Results: We found that systemic administration of only nilvadipine among these Ca2+ antagonists caused preservation of retinal morphology and functions of electroretinogram responses in RCS rats during the initial stage of the retinal degeneration. Studies using immunohistochemistry, RT–PCR and Western blotting revealed significant enhancement of rhodopsin kinase and a–A–crystalline expressions, and suppression of caspase 1 and 2 expressions in the retina of nilvadipine treated rats. Conclusions: Based upon these data, it is suggested that nilvadipine is beneficial for the preservation of photoreceptor cells in RCS rats and can potentially be used to treat some RP patients.

Keywords: apoptosis/cell death • calcium • retinal degenerations: cell biology 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×