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G.L. Fenton, J. Zink, S. Mian; Risk of Traumatic Endophthalmitis With and Without Intravenous Antibiotic Prophylaxis . Invest. Ophthalmol. Vis. Sci. 2004;45(13):3999.
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Purpose:The goal of this study is to determine whether prophylactic intravenous antibiotics reduce the incidence of endophthalmitis following traumatic open globe injury. Methods:Retrospective chart review of 292 patients presenting with traumatic open globe injury. The mean age was 34.38 +/– 22.8 years (2–99) with 80.8% male (236/292) and 19.2% female (56/292). Results:Visual acuity at presentation was > or = 20/400 in 20.0% (58/292), less than 20/400 to CF in 12.7% (37/292), HM to LP in 37.0% (108/292), and NLP in 14.7% (43/292). Visual acuity at last follow–up was greater than or = 20/400 in 50.3% (147/292), <20/400 to CF in 5.8% (17/292), HM to LP in 13.0% (38/292), and NLP in 27.1% (79/292) with 19.2% (56/292) requiring enucleation. The overall incidence of endophthalmitis was 2.1% (6/292). Endophthalmitis incidence for patients receiving no intravenous antibiotics was 3.1% (4/131). This value was not significantly different compared to those who received < 24 hours of perioperative/postoperative intravenous antibiotics 1/121 (0.83%) or those who received greater than or = 24 hours of perioperative/postoperative intravenous antibiotics 1/4(2.5%). Conclusions:Intravenous antibiotics may not reduce the incidence of endophthalmitis after traumatic open globe repair. Postoperative inpatient care for traumatic open globe injuries may not be necessary.
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