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C.N. Ta, M. Kossakiewicz, L. He, M.S. Blumenkranz, H. Miño de Kaspar; Impact of Topical Ofloxacin on the Resistance Rate of Coagulase–Negative Staphylococci to Fluoroquinolones in Patients Undergoing Intraocular Surgery . Invest. Ophthalmol. Vis. Sci. 2004;45(13):4000.
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Purpose:To determine whether the application of topical ofloxacin increases the resistance rate of coagulase–negative staphylococci (CNS) to fluoroquinolones. Methods:Conjunctival cultures were obtained at baseline (prior to exposure to ofloxacin) and after treatment with ofloxacin and povidone–iodine in patients undergoing intraocular surgery. Treatment consisted of a combination of three applications of ofloxacin, five minutes apart, ofloxacin four times a day for three days, or two drops of povidone–iodine before surgery. One–hundred and twenty–four strains of CNS were obtained at baseline, and 77 were obtained after treatment. Antibiotic resistance to the fluoroquinolones was determined using the Kirby–Bauer disc–diffusion technique. Results: View OriginalDownload SlideView OriginalDownload Slide Table 1. Number of coagulase–negative staphylococci resistant to the antibiotic tested. "n" indicates the total number of samples, Cipro = ciprofloxacin, Oflox = ofloxacin, Norflx = norfloxacin, Levo = levofloxacin, Gati = gatifloxacin, Moxi = moxifloxacin. Conclusion:Exposure to ofloxacin of short duration does not appear to increase the number of fluoroquinolone–resistant CNS strains isolated from the conjunctiva in patients undergoing intraocular surgery.
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